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It's the first car developed together by Nissan and Italdesign

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2018 GT-R
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When car companies celebrate anniversaries, the results can be a bit underwhelming, such as the paint and badge job Chevy put together for its truck anniversary . The Nissan GT-R50 by Italdesign is not one of those vehicles. It's a custom based on a Best Store To Get Cheap Price Cool Shopping Tory Burch Jelly Thong Sandals Buy Cheap Sast k6YkG
featuring unique bodywork from the famed Italian design company. It's the first time Italdesign has worked with Nissan, and perhaps they should work together more often. The GT-R50 has a lower nose, a lower roof, and wider fenders. It's one of the meanest-looking GT-Rs yet. It has performance to backup the looks, too. The normal GT-R's twin-turbocharged 3.8-liter V6 has been supplemented with big turbos from the GT3-class race car, along with bigger intercoolers, more aggressive cams and beefier internals including the pistons, rods, bearings and crankshaft. Combined, they allow the V6 to produce 710 horsepower and 575 pound-feet of torque. That's an increase of 110 horsepower and 94 pound-feet over the regular GT-R NISMO. Nissan made sure the rest of the car was ready for all the extra power, too. The differentials and axles are stronger to ensure nothing breaks when launching. Brembo six-piston brakes sit up front with four-piston units in the rear to stop the beast, and a Bilstein active suspension helps it corner. Finally, the interior was updated to make it as special as the Italdesign exterior. Everything inside was designed by Nissan's U.S. and London design teams. It features loads of carbon fiber, Alcantara, and gold accents. The latter helps tie things together with the gold elements on the exterior. No plans for a production version of the GT-R50 have been announced. Nissan also emphasized that this is not a preview of the next generation GT-R. It's just a special celebration of the model and the design company. Related Video:
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Photographer Joel Meyerowitz captured objects in Cézanne’s studio against a grey wall, considering the influence of this background on the artist’s work.

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In his final years, Paul Cézanne worked from a quiet studio in Aix-en-Provence,having returned to live in his hometown as his health waned. He had long been nomadic, traveling between Paris and the south of France, and this studio of his own design was packed with objects from his life. Pitchers, glass bottles, and ceramic containers lined an overhead shelf, presided over by a crucifix (a sign of his return to Catholicism); outside was a view to Mont Sainte-Victoire, which he painted numerous times .The studio even had a specially-designed portal so Cézanne could move big canvases like his “ Les Grandes Baigneuses ” to the garden, to paint in the natural light.

The studio is preserved as Cézanne left it when he died of pneumonia in 1906. When photographer Joel Meyerowitz visited the space, he was struck by its lighting and the studio walls, which were painted in a dark grey color Cézanne mixed himself. When an object was viewed in front of this wall, illuminated by a large north-facing window, it seemed to lose its depth, a quality that remindedMeyerowitz of the flatness in Cézanne’s paintings. With permission from the director of the atelier,Meyerowitz methodically photographed the objects in Cézanne’s studio against this wall. The series of 65 photographs is published in MONSIEUR Slipons noir New Cheap Price Clearance Explore 3BOEOI
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“The play of light on this particular tone of grey was a precisely keyed background hum that allowed a new exchange between, say, the red of an apple and the equal value of the grey background,” Meyerowitz writes in a book essay. “It was a proposal of tonal nearness that welcomed the idea of flatness.” He adds, “I wanted to see for myself how a photograph would treat these objects and their relationship to the wall, while the changing variations of afternoon light played across the grey background, offering a meditation on the dimensions of perception.”

HDL activation of endothelial sphingosine-1-phosphate receptor-1 (S1P1) promotes regeneration and suppresses fibrosis in the liver .

Ding, Bi-Sen; Liu, Catherine H; Sun, Yue; Chen, Yutian; Swendeman, Steven L; Jung, Bongnam; Chavez, Deebly; Cao, Zhongwei; Christoffersen, Christina; Nielsen, Lars Bo; Schwab, Susan R; Rafii, Shahin; Hla, Timothy

2016-12-22

Regeneration of hepatic sinusoidal vasculature is essential for non-fibrotic liver regrowth and restoration of its metabolic capacity. However, little is known about how this specialized vascular niche is regenerated . Here we show that activation of endothelial sphingosine-1-phosphate receptor-1 (S1P 1 ) by its natural ligand bound to HDL (HDL-S1P) induces liver regeneration and curtails fibrosis. In mice lacking HDL-S1P, liver regeneration after partial hepatectomy was impeded and associated with aberrant vascular remodeling, thrombosis and peri-sinusoidal fibrosis. Notably, this "maladaptive repair" phenotype was recapitulated in mice that lack S1P 1 in the endothelium. Reciprocally, enhanced plasma levels of HDL-S1P or administration of SEW2871, a pharmacological agonist specific for S1P 1 enhanced regeneration of metabolically functional vasculature and alleviated fibrosis in mouse chronic injury and cholestasis models. This study shows that natural and pharmacological ligands modulate endothelial S1P 1 to stimulate liver regeneration and inhibit fibrosis, suggesting that activation of this pathway may be a novel therapeutic strategy for liver fibrosis.

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Vieira Ramos, Gracielle; Pinheiro, Clara Maria; Messa, Sabrina Peviani; Delfino, Gabriel Borges; Marqueti, Rita de Cássia; Salvini, Tania de Fátima; Durigan, Joao Luiz Quagliotti

2016-01-04

The application of cryotherapy is widely used in sports medicine today. Cooling could minimize secondary hypoxic injury through the reduction of cellular metabolism and injury area. Conflicting results have also suggested cryotherapy could delay and impair the regeneration process. There are no definitive findings about the effects of cryotherapy on the process of muscle regeneration . The aim of the present study was to evaluate the effects of a clinical-like cryotherapy on inflammation, regeneration and extracellular matrix (ECM) remodeling on the Tibialis anterior (TA) muscle of rats 3, 7 and 14 days post-injury. It was observed that the intermittent application of cryotherapy (three 30-minute sessions, every 2 h) in the first 48 h post-injury decreased inflammatory processes (mRNA levels of TNF-α, NF-κB, TGF-β and MMP-9 and macrophage percentage). Cryotherapy did not alter regeneration markers such as injury area, desmin and Myod expression. Despite regulating Collagen I and III and their growth factors, cryotherapy did not alter collagen deposition. In summary, clinical-like cryotherapy reduces the inflammatory process through the decrease of macrophage infiltration and the accumulation of the inflammatory key markers without influencing muscle injury area and ECM remodeling.

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User Guide

First time using the AWS CLI? See the User Guide for help getting started.

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Describes the specified attribute of the specified instance. You can specify only one attribute at a time. Valid attribute values are: | | | | | | | | | | | |

See also: AWS API Documentation

See for descriptions of global parameters.

--attribute (string)

The instance attribute.

Note: The attribute is not supported at this time.

Possible values:

--dry-run | --no-dry-run (boolean)

Checks whether you have the required permissions for the action, without actually making the request, and provides an error response. If you have the required permissions, the error response is . Otherwise, it is .

--instance-id (string)

The ID of the instance.

--cli-input-json (string) Performs service operation based on the JSON string provided. The JSON string follows the format provided by --generate-cli-skeleton . If other arguments are provided on the command line, the CLI values will override the JSON-provided values.

--generate-cli-skeleton (string) Prints a JSON skeleton to standard output without sending an API request. If provided with no value or the value input , prints a sample input JSON that can be used as an argument for --cli-input-json . If provided with the value output , it validates the command inputs and returns a sample output JSON for that command.

See 'aws help' for descriptions of global parameters.

To describe the instance type

This example describes the instance type of the specified instance.

Command:

Output:

To describe the disableApiTermination attribute

This example describes the disableApiTermination attribute of the specified instance.

To describe the block device mapping for an instance

This example describes the blockDeviceMapping attribute of the specified instance.

Here's some info you may need: